In 1996, he was awarded the MSc in Chemistry title at the Faculty of Chemistry of Adam Mickiewicz University in Poznań; his thesis Theoretical analysis of selected (R,R)-tartaric acid derivatives, supervised by Jacek Rychlewski, was awarded the first prize in Faculty's Contest for the best MSc dissertation of that year.

In 1997, he achieved MSc in Biotechnology at the AMU Faculty of Biology for his thesis Properties of glycoproteins isolated from Chelidonium majus milky sap, supervised by Anna Goździcka-Józefiak.

[2] He defended his habilitation thesis Quantum-chemical calculations in molecular modelling of selected systems of importance in chemistry, biochemistry, and medicine[5] in 2009 and became an associate professor two years later.

For many years, Hoffmann has been actively working for the expansion of Adam Mickiewicz University's scientific and educational abilities, for example by initiating and co-authoring AMU – supranational and interdisciplinary solutions of 21st century (pl.

UAM – ponadnarodowe i interdyscyplinarne rozwiązania XXI wieku) – a project co-funded by the National Centre for Research and Development, carried out in cooperation with the University of Massachusetts Lowell, and co-authoring BSc, MSc and PhD course programmes at the Faculty of Chemistry.

[38] Aside from his academic work, Hoffmann has been widely cooperating with high-tech enterprises, implementing the idea of knowledge-based economy, for almost twenty years.

In 2002–2003, he worked as McKinsey & Company consultant, managing telecommunications and energy carriers; in 2004, he became the Director for Investments & Development at BioInfoBank Institute.

[39] Well-aimed investments of the company, led by Hoffmann to the present day, allowed it to multiply its financial resources, and some of the startups it had funded became global players, such as: Since 2010, he has worked as expert witness of the District Court in Poznań in exact sciences, economic sciences and enterprise; he has also issued expert opinions for courts in other cities, including Warsaw, Myślibórz and Łowicz.