He is best known as a previous chief of staff of United States Customs and Border Protection who served from 2009 to 2011 under CBP Commissioner Alan Bersin, and as senior advisor to the U.S.-based foundation of billionaire Carlos Slim focused on broadband connectivity for all and free online education.

[citation needed] Lopez earned a bachelor's degree in liberal studies and political science from the University of Arizona.

[8][9] In 2011, Lopez founded Intermestic Partners, one of the top international business development and political advisory firms in North America.

[3] According to multiple references in print and online media, since 2011, Marco Lopez has served as a senior advisor to the U.S. Foundation of Mexican billionaire Carlos Slim Helu,[1][2][3] who was ranked from 2010 to 2013 by Forbes magazine as the richest person in the world.

The foundation's work initiated with the launch of Connect2Compete a low-cost broadband adoption program to connect eligible working-class families to the internet.