Marco Antonio Adame Castillo (born 6 December 1960) is a Mexican politician, medical doctor, and member of the National Action Party (PAN).

On June 27, 2009, the Fiscalía Especial para la Atención de Delitos Electorales ("Special prosecutor for the attention of electoral crimes") accused Governor Marco Adame of transferring MXN $15 million of state funds to electoral purposes in favor of Sergio Álvarez Mata, candidate for mayor of Cuernavaca and Adriana Vieyra Olivares, candidate for deputy, both members of the National Action Party.

[1] On January 11, 2010, the Mexican government's organized crime division SIEDO received an anonymous tip accusing the governor's bodyguards of being personally linked to the Beltrán-Leyva Cartel.

[2] Marco Antonio was one of ten siblings, two of whom, Humberto and Edgar, were appointed to public office by Governor Adame Castillo.

[3] Roberto Adame Castillo, 58, brother of Marco Antonio, committed suicide by hanging on June 7, 2013, in Cocoyoc, Morelos.