Marcos Zucker was born into a Polish-Jewish family who immigrated to the country at the beginning of the 20th century during the great European emigration.

He worked in several successful comedy programs on television from the 1960s to the 1990s, especially in the acclaimed comedy-skit La Tuerca.

He also acted in several movies and in theatre in Argentina and Chile where he worked for seven seasons doing Fiddler on the Roof.

During the military dictatorship called the National Reorganization Process (1976–1983) one of his sons, Ricardo Marcos was abducted by security forces, becoming a disappeared.

Zucker died of a heart attack on 13 May 2003 and was buried in the actors pantheon at Chacarita Cemetery in Buenos Aires.