Marcos de Niza High School is a high school located in Tempe, Arizona.

It was founded in 1971 and it has an enrollment of approximately 1,500 students.

The school is a part of the Tempe Union High School District and mainly serves students in central Tempe, as well as the Town of Guadalupe.

The Tempe High School District hired the local architecture office of Michael & Kemper Goodwin Ltd. to design the new school.

Kemper Goodwin along with his son Michael began drawing up plans for the campus in 1969.