Thigpen was also a member of the Denver Broncos, Hamilton Tiger-Cats, Miami Dolphins, New England Patriots, Tampa Bay Buccaneers, Buffalo Bills, Indianapolis Colts, Oakland Raiders, and Saskatchewan Roughriders.

Thigpen attended Mumford High School in Detroit, Michigan and was a letterman in football and track.

After high school, Thigpen enrolled at Indiana University but was redshirted his freshman year.

During his four years of competition (2005-2008), he finished his career as the third best kick returner (2,009 yards) in the school's history.

He was selected as one of the team's captains as a fifth-year senior and was named IU's offensive player of the year in 2008.

[1] Thigpen led the Hoosiers with a 2006 season-best time of 10.65 in the 100 meters, which he clocked at the Big Ten Outdoor Championships, good for sixth place.

On September 9, 2012, Thigpen returned a punt 72 yards for a touchdown in his first NFL game versus the Houston Texans.

On December 15, 2013, he caught a 14-yard touchdown strike from Ryan Tannehill with 1:15 left in the 4th quarter to provide the winning margin over the New England Patriots, which put an end to the Patriots' string of three come-from-behind victories in 2013 and also snapped the Dolphins' seven-game losing streak to New England.

Due to an injury to starter Leodis McKelvin, Thigpen was claimed off waivers by the Buffalo Bills on November 26, 2014.

It also earned Thigpen Peter King's MMQB Special Teams Player of the Week Award.

[7] Thigpen was released from the Bills on October 7 in favor of wide receiver Denarius Moore.

[11] On September 12, 2017, the Saskatchewan Roughriders announced that they had signed Thigpen to their practice roster as a kick returner.

[16] After the CFL canceled the 2020 season due to the COVID-19 pandemic, Thigpen chose to opt-out of his contract with the Argonauts on September 3, 2020.