Marguerite d'Enghien (born 1365 - d. after 1394), was the ruling suo jure Countess of Brienne and of Conversano, suo jure Lady of Enghien, and Lady of Beauvois from 1394 until an unknown date.

[1] Marguerite had a brother, Antoine who died at the age of sixteen, leaving her, the eldest daughter, heir to her father's estates and titles.

Marguerite became the suo jure Countess of Brienne and Conversano, and Dame of Enghien upon her father's death on 17 March 1394.

Her eldest son, Peter received her titles of Brienne and of Conversano.

In 1380, after Giacopo's death, Marguerite married her third husband, John of Luxembourg, Sire of Beauvois (1370–1397).