Louis was the fourth son of Walter III of Enghien and Isabella of Brienne.

When his mother divided the inheritance of his uncle Walter VI of Brienne among her sons, he received the title of Count of Conversano.

In 1370, after Philip II of Taranto had secured the undisputed control of the Principality of Achaea against Maria of Bourbon, he was sent as Philip's bailli to the principality, which also included the lordship of Argos and Nauplia, ruled by his brother Guy.

[1] From this position he and his brothers, including John of Enghien, wrote to the Doge of Venice to request Venetian aid in reclaiming the Duchy of Athens, which had been in their family's hands until 1311, from the Catalan Company, but help was not forthcoming.

On his death, at Conversano, on March 17, 1394, his titles were inherited by his eldest daughter Peter I married in his own turn, Margaret de Baux, by whom he had nine children: among them are Louis, Count of St. Pol, Brienne, and Conversano, and Jacquetta (mother of Queen consort Elizabeth Woodville).