Margaret Anne has been featured in major motion pictures, television, independent films, and on the New York stage.
[3] Florence co-starred as Rosemary Keenan, alongside Carla Gugino and Ellen Burstyn, in The Mighty Macs,[citation needed] released nationwide on October 21, 2011 and based on the true story of Basketball Hall of Fame coach Cathy Rush, who led Immaculata University to the 1972 National Women's Collegiate Championship.
Florence was cast in the lead role of Clara Johnson in a 2010 production of The Light in the Piazza, at Washington, D.C.'s Arena Stage.
[10] Florence appeared in regional productions of Godspell, Little Shop of Horrors, Maccabeat!, Company, Street Scene (based on the Pulitzer Prize winning play by Elmer Rice), and Jacques Brel is Alive and Well and Living in Paris.
[1] Florence starred in Death Cab for Cutie's music video for What Sarah Said[11] from the band's 2005 studio album, Plans.