[3] She attended Packer Collegiate Institute, Syracuse University, and the Art Students League of New York, as well as took lessons with John Hovannes.

Many of her pieces depicted contemporary life and tackled current issues of the day, including socioeconomic injustice and war.

[3][5] One of Brassler Kane's best-known works is a group of large relief panels carved in limewood, each six by six feet: Symbols of Changing Man (1937–39), Earthbound (1950–57), and Micro-Macrocosm (1960–67).

[3] The panels depict the history of humanity, exploring themes of science, technology, industry, religion, and social conflict.

"[7] Bread and Wine (1940) is a bronze work that contrasts impoverished figures on a Great Depression-era breadline with well-off bargoers mingling over cocktails.