Sir Thomas More was her legal guardian, bringing her up from a child with his own daughter who was also named Margaret.
[1] Algebra was probably her special study and More had an "algorisme stone" of hers with him in the Tower of London during his imprisonment, which he sent back to her the day before his execution in 1535.
Sir Thomas Elyot had conveyed to her and her husband the indignation felt by Emperor Charles V, Catherine of Aragon's nephew, at More's resignation, but William Roper, writing years later, had the emperor talking about More's execution; as R. W. Chambers points out, Elyot was not ambassador to the imperial court when More died.
[2] She remained a Roman Catholic, and died in exile at Mechlin, Duchy of Brabant, in the Habsburg Netherlands on 6 July 1570.
She also had an outstanding command of Greek, as noted by Spanish scholar Juan Luis Vives.