In 1900 Hamilton was back home to Fort Wayne, where she took care of her younger 4-year-old brother, Quintus, and then joined the faculty at Bryn Mawr School, Baltimore, as Science teacher.
[3][1] Clara Landsberg, a close colleague and longtime family friend, studied in Europe with Margaret Hamilton for a summer in 1899 and was to become her lifetime companion.
The daughter of a Reform rabbi from Rochester, New York, and a graduate of Bryn Mawr College, Landsberg became a resident at Hull House, where she was in charge of its evening education programs and shared a room with Alice Hamilton.
Landsberg eventually left Hull House to teach Latin at Bryn Mawr School, where Edith Hamilton was headmistress.
"[2] The Hamilton sisters, their mother, Edith's companion, Doris Fielding Reid, and Landsberg, spent their retirement years in Hadlyme, Connecticut, at the house they purchased in 1916.