Margaret Nakikus (died 1992) was the first Papua New Guinean woman to head that country's National Planning Office.

Margaret Latatuai Nakikus came from Matupit, near Rabaul in the East New Britain province of Papua New Guinea (PNG).

Her early research interest seems to have been focused on migration, particularly on resettlement schemes in PNG that involved moving people from the Highlands Region to coastal and island locations to cultivate oil palm.

This coincided with the initiation of PNG's Literacy and Awareness Programme and Nakikus chaired the national ILY committee.

After his defeat in parliament in 1992 he left politics to be with Nakikus, who had incurable leukaemia and was in hospital in Brisbane, Australia.