Margaret Palaeologa (Italian: Margherita Paleologa; 11 August 1510 in Casale Monferrato – 28 December 1566 in Mantua), was the ruling Marquise regnant of Montferrat in her own right between 1533 and 1536.

Having weighed up the various proposals for Margaret's hand, her mother Anne d'Alençon opted for the link with the House of Gonzaga and the marriage was concluded in October 1531.

Margaret had her son married to Catherine, daughter of Ferdinand I, Holy Roman Emperor and Anna of Bohemia and Hungary.

As regent, Margaret issued laws and regulations which benefitted the economy of Mantua by the establishment of businesses.

In her foreign policy, she was pro-Spanish, which caused the French king to occupy Montferrat in 1555 - it was to be held by France until the Treaty of Cambresis in 1559.