Margaret Seddon (November 18, 1872 – April 17, 1968) was an American stage and film actress.

Her most memorable role was perhaps as one of The Pixilated Sisters, a comedic stage act with actress Margaret McWade.

In 1936, they reprised their roles in the film Mr Deeds Goes to Town.

On Broadway, Seddon performed in Modern Marriage (1911) and The Things That Count (1913).

[1] She was born in Washington, D.C., and died in Philadelphia, Pennsylvania.