Margaret is also the founder of MaMa FM[2] and the executive director of Uganda Media Women's Association (UMWA)[3] She was born in Masaka to Edward Patrick Ssentamu and Theresa Nakalema Ssentamu who are now both dead.
Margaret is also a sister to John Ddumba Ssentamu the former Vice Chancellor of Makerere University.
[1] She did PGD in journalism at Uganda Management Institute (UMI) and then did a Postgraduate Diploma in Mass Communication in 1985 at the University of Nairobi, before going back to Makerere University for a master's degree in Women and Gender Studies.
[2] While for her bachelor's degree at Makerere University, Margaret was very active in student politics as a member of the Democratic Party and a guild representative for Mary Stuart Hall and this led to her winning of the scholarship for her Postgraduate Diploma at the University of Nairobi.
[1] When she completed her postgraduate, she intern as a reporter at the Nation Media Group in Nairobi, and a correspondent for the Harare office of the Inter Press Service for one year.