Her father, William Wake, served as the East India Company's Governor of Bombay from 1742 to 1750.

[3] On 26 December 1757 she married William Tryon of Norbury Park, a captain in the 1st Regiment of Foot Guards and a grandson of Robert Shirley, 1st Earl Ferrers, at St. George's Church.

In 1764 Wake moved with her husband to the Province of North Carolina, where he served as Lieutenant Governor.

In 1770 they moved into Tryon Palace in New Bern, which they had built as the official residence for the Governor of North Carolina.

[3] She was known to avoid women's company and preferred to engage in men's conversation, particularly on the topics of government and military fortifications, which was considered unconventional at the time.

Wake is portrayed by Melanie Gray in the fourth season of the British television series Outlander.