Margarita del Mazo earned a law degree from the Complutense University of Madrid.

In the late 1990s, she began narrating live stories, and in 2009, she published her first book, La máscara del león.

She collaborates with the Instituto Cervantes[1] on several of its festivals (Day E, Festival Ñ and Cervantino Day of Children's and Young Adult Literature), in different national and international venues, with presentations, workshops, author meetings and narration sessions.

She also works with institutions such as the Museo Nacional Centro de Arte Reina Sofía, the Museo ABC, the Thyssen-Bornemisza Museum, the Community of Madrid, Castilla–La Mancha, the Centro Andaluz de las Letras [es], the Casa del Lector [es] in Matadero, town halls, hospitals, festivals (BITA, Etnosur, Hay Festival, etc.

In 2017, she was invited to Chicago and other communities in Illinois, to participate in narration sessions and meetings with authors and teachers in bilingual centers and libraries.