The younger, Giacomo, was made a cardinal in 1278 by Pope Nicholas III, an Orsini cousin.
Cardinal Colonna was a friend and confidant of Pope Honorius IV, and a leading figure of the papal curia.
[5] She retired to Castel San Pietro, a lonely retreat near Palestrina where she passed her time in practices of piety and penance.
[1] In 1285 Pope Honorius IV granted the monastery of San Silvestro in Capite to her followers, who at that time were incorporated into a formal Franciscan community, adopting the rule of the Sorores minores, which had been approved for Isabelle of France, the sister of Louis IX of France, in 1263.
After the first biography written by her brother, a second was composed by a woman named Stefania, who had been a leader of the community stemming from Margherita's followers.