She was renowned for a number of major public commissions and for her landscaping and interior design for the family home at Emu Plains.
[1] In the late 1920s she attended Antonio Dattilo-Rubbo's evening art classes where she met her future husband, Gerald Lewers.
[5] Following the initiative in landscape design and outdoor sculpture that the pair made in their new home, in 1957, Lewers and Gerald were commissioned to create a garden of pebbles, cacti and sandstone for the MLC Building in North Sydney.
Two years later, Gerald died, and in 1965 Lewers completed his major public commission, "Expansion", for the Reserve Bank in Canberra.
In 1966, Lewers held a solo show of paintings at Macquarie Galleries, and in 1968 she received a further major commission from the Reserve Bank of Australia for a tapestry for their boardroom.
Margo Lewers exhibited frequently throughout her lifetime in both group and solo shows and her work was collected by major state galleries.
While still alive, Lewers began the process of bequeathing her home and the couple's collection of artworks to the local community.