[2] Maria-Ana Tupan was born in Sărulești, Buzău County, Romania, the daughter of Margareta (née Constantin) and Spiridon Iordache, a priest.

[3] Tupan made her publishing debut in 1980 with Regele visurilor (The King of Dreams), an anthology of translations from American prose of the 19th century.

[6][7] In 2014 she completed her habilitation thesis[8] and became affiliated with the Doctoral School of Alba Iulia University, supervising PhD students.

[4] Her 17 books and a number of articles published in Europe, India, United States, and Australia are based on theoretical underpinnings falling within the fields of epistemology of literature, philosophy of culture, literary history and theory.

[11][12] Her literary chronicles and essays have been published in Convorbiri literare, Contemporanul, Luceafărul, România literară, Viața Românească magazines.