Maria Angelina Doukaina Palaiologina or Marija Angelina Nemanjić or Anna Maria Angelina Doukaina Palaiologina (Greek: Μαρία Αγγελίνα Δούκαινα Παλαιολογίνα, Serbian Cyrillic: Марија Ангелина Немањић; 1349 – 28 December 1394) was a Byzantine Greek-Serbian aristocrat and the self-proclaimed basilissa (Greek: βασίλισσα; Empress, queen) of Epirus from 1384–85, succeeding the rule of her murdered husband Thomas Preljubović.

In 1361, Maria, then only 12 years old, married Thomas Preljubović, who was appointed the governor (despot) of Epirus in Ioannina by her father in 1366.

[3] She summoned her brother John Uroš Doukas Palaiologos (who became a monk in Meteora monastery by the name of Joasaph)[4] to advise her in the affairs of state, though he didn't stay long.

John Uroš suggested that Maria marry Esau de' Buondelmonti, one of the Latin noblemen captured by Thomas in 1379.

It has been alleged[5] that Maria was already enamored of the captive before the murder of her husband, and that this affair had resulted in the assassination of Thomas.