Princess Maria Anna of Naples and Sicily (Italian: Maria Anna Giuseppa Antonietta Francesca Gaetana Teresa Amalia Clementina; 23 November 1775 – 22 February 1780) was a member of the Spanish Royal Family (branched out to the Kingdom of the Two Sicilies).

Her father was Ferdinand, Duke of Calabria, the third son and ninth child of Charles III of Spain and Maria Amalia of Saxony.

Her full name was Maria Anna Giuseppa Antoinette Francesca Gaetana Teresa Amalia Clementina, her first four names were the same as her mother's eldest sister Archduchess Maria Anna of Austria (1738-1789).

Due to the fact that Maria Anna was born just ten months after her older brother Carlo Francesco Giuseppe Gennaro, her birth was extremely difficult for Maria Carolina, and thus for the baby too.

Her health was reason for debate and when her brother Carlo, Duke of Calabria became ill with smallpox, he was immediately transferred to the Caserta Palace in order to prevent Maria Anna from getting sick, too.