Princess Maria Clotilde of Naples and Sicily (Italian: Maria Clotilda Teresa Amelia Antonietta Giovanna Battista Anna Gaetana Pulcheria; 18 February 1786 – 10 September 1792) was a member of the House of Bourbon in the Kingdom of the Two Sicilies.

Her father was Ferdinand, Duke of Calabria, the third son and ninth child of Charles III of Spain and Maria Amalia of Saxony.

Her full name was Maria Clotilda Teresa Amelia Antonietta Giovanna Battista Anna Gaetana Pulcheria.

In the case of Maria Clotilde, this was the result of a cold in 1786, when the princess was just a few days old.

She then passed it on to her sister Maria Henrietta, but both recovered yet they remained very very frail and the smallpox returned to Maria Clotide in September 1792, who yet again passed it on to her sister, the two dying within ten days of each other.