As a journalist with RTP, the Portuguese Public Television, she was the author and hostess of her own political and cultural talk shows since 1977.

She received and interviewed most of the Presidents, Prime Ministers and other politicians, writers, painters and many other relevant cultural Portuguese personalities as well as business men and union leaders, among many others.

In her life Maria Elisa Domingues had other professional experiences: she was the Press Counselor to Prime Minister Maria de Lourdes Pintasilgo (1979/1980); Program Director of RTP[2] (1980–1983 and 1998–1999); Press Counselor with the Portuguese Embassy in Madrid (1986–1987); Director of Communication of the Calouste Gulbenkian Foundation (1995–1998) and Cultural Counselor with the Portuguese Embassy in London (2004–2006).

Maria Elisa nowadays is the President of Associação dos Jornalistas Europeus (the Portuguese association of European Journalists) and also a regular contributor to some of Portugal's largest newspapers and news magazines, such as Diário de Notícias, Público, Expresso and Visão.

She is a member of Myos—Associação Nacional Contra a Fibromialgia e Síndrome de Fadiga Crónica (Fibromyalgia and Chronic Fatigue National Association).