Born to the Duke and Duchess of Savoy at the Royal Palace of Turin, she was the couple's eldest daughter.
Her sisters included the future "grand daughters-in-law" of Louis XV of France: Princess Maria Giuseppina and Princess Maria Teresa.
Her brothers included the last three kings of Sardinia from the mainline; the future Charles Emmanuel IV, Victor Emmanuel I and Charles Felix of Sardinia.
Maria Elisabetta died on 17 April 1753, in Turin, aged only 9 months.
[1] She was buried in the Basilica of Superga, traditional burial site of members of the House of Savoy.