Leopoldina Maria, Princess of Savoy was born at the Palazzo Carignano in Turin, the capital of the Kingdom of Sardinia.

As such, Charles Emmanuel's children were Leopoldina's first cousins including the future King Victor Amadeus III of Sardinia.

Her brothers included Victor Amadeus II, Prince of Carignano, grandfather of King Charles Albert of Sardinia.

The second of six daughters, her most famous sister was Maria Luisa of Savoy, future wife of Louis Alexandre de Bourbon and friend of Marie Antoinette and immortalised as the princesse de Lamballe.

Andrea IV who was a frequent at the court at the Royal Palace of Turin and the Castle of Racconigi, the latter of which was a personal residence of the Princes of Carignano.