Maria Agasovna Guleghina[a] (née Meytardjan (Russian: Мейтарджян); born 9 August 1959) is a Soviet-born operatic soprano singer, particularly associated with the Italian repertory.

Guleghina made her stage debut in 1985 as Yolantha at the State Opera in Minsk (Belarus) shortly before leaving USSR to pursue an international career.

Her international debut came in 1987 as Amelia (opposite Luciano Pavarotti's Riccardo) in a production of Un ballo in maschera at La Scala.

Leading roles in I due Foscari, Manon Lescaut, and Tosca followed, and soon she was engaged to perform in Vienna, Munich, Hamburg, London, and other major European opera houses.

Guleghina also participated of the Opening Ceremonies of the 2014 Winter Paralympics, singing "Cossack Lullaby" on top of an icebreaker that carried her though the stadium.