Her work on pop culture has appeared in publications such as Empire, Penthouse, Junkee, New York Post, The Guardian, i09, The Daily and Sunday Telegraph, BuzzFeed, and others.

Lewis was known for her role as a panelist, presenter, writer and producer[3] on SBS Viceland's nightly news program The Feed[4] and is an ambassador for the Australian Stroke Foundation[5] after surviving a Transient ischemic attack (TIA) when she was twenty-two.

[13] She primarily works as a screenwriter for film and television, including projects for AMC, Netflix, SBS, Ubisoft, ABC, Stan, DC Comics, and has curated seasons at the Australian Centre for the Moving Image on Creature from the Black Lagoon,[14] Aussie neo-noir (titled Yeah Noir[15]), Australian rom-coms (Yeah The Girls) and cult classics like Birds Of Prey, Candyman and Mad Max: Fury Road (ACMI Watches).

was published globally in 2015[19] and kickstarted the eight-book Supernatural Sisters series which "examined the feminine grotesque and the idea of female monsters".

Lewis' first crime-fiction novel, The Graveyard Shift - was acquired by Angry Robot and announced on Halloween 2022, with The Bookseller calling it "slasher-crime for the millennial generation".