She was a daughter of Andrea III Muzaka and his wife Chiranna Zenevisi, Lady of Grabossa.

From her marriage to Gjergj Arianiti, Maria had eight daughters, most notably of them were Andronika, Queen of Albania, and Saint Angjelina, Empress of Serbia.

Her mother, Chiranna "Anna" Zenevisi, is mentioned in Gjon Muzaka's Chronicles as Lady of Grabossa and a daughter of Giovanni Sarbissa (alb.

The couple had eight daughters:[1] After her death, around the 1440s, Arianiti married Italian noblewoman Pietrina Francone, with whom he went on to have five more children.

[1] Maria's eldest daughter, Andronika, is traditionally recognised as the first Albanian Queen through her marriage to Albania's national hero George Castriot Scanderbeg.