3 by the WTA, which she first achieved on 21 March 2022, making her the highest-ranked Greek player, tied with Stefanos Tsitsipas.

[16] In the qualifying, she beat Anastasija Sevastova, An-Sophie Mestach and Petra Martić, but then lost in the first round of the main draw to Wang Qiang.

[22] Her second win on the WTA Tour was at the Istanbul Cup, where she defeated top seed Anna Karolína Schmiedlová.

After beating Hsieh Su-wei in the second round, she reached her first WTA Tour quarterfinal, where she lost to Danka Kovinić.

[23] In Madrid, she failed to reach the main draw, losing to Patricia Maria Țig in the final stage of qualifying.

[24] Competing the qualifying at the 2016 French Open, she missed the chance to play in the main draw, losing her first match to Grace Min.

[42][43][44][45] In Dubai, she reached the final stage of qualification, but did not make it to the main draw, losing to Samantha Stosur.

At the Miami Open, she defeated Aleksandra Krunić and 28th seed Anett Kontaveit, and reached the third round where she lost to Monica Puig.

[49] Sakkari started her clay-court season by reaching her first semifinal in 2018 in (Istanbul) where she beat Çağla Büyükakçay, Aleksandra Krunić and Arantxa Rus, respectively, before losing to Polona Hercog.

She was defeated by Julia Görges at the Birmingham Classic, Svetlana Kuznetsova at the Eastbourne International, and by Sofia Kenin at Wimbledon.

[60][61] At Cincinnati, she beat Naomi Osaka in the first round and avenged her loss in Indian Wells earlier that year.

Sakkari reached the third round at the Australian Open, defeating Jeļena Ostapenko and Astra Sharma, before she was eliminated by Ashleigh Barty.

[66][67][68] At next three tournaments, Sakkari was eliminated in the first rounds: at St. Petersburg by Julia Görges, at the Mexican Open by Monica Puig, and at Indian Wells by Christina McHale.

As it regards the clay-court season, she started playing at Charleston Open, where she defeated Conny Perrin, Andrea Petkovic and second seed Kiki Bertens, respectively.

She defeated Stefanie Vögele, Bernarda Pera and Amanda Anisimova, before Serena Williams stopped her from reaching her first Grand Slam quarterfinal.

[92] Sakkari started off the season strongly making the quarterfinals of the Abu Dhabi Open without dropping a set with wins over Anastasia Potapova, Coco Gauff and Garbiñe Muguruza.

She then backed this up with a semifinal appearance at the Grampians Trophy before losing to Anett Kontaveit in a three set thriller.

She then saved six match points in a three-set thriller against surging Jessica Pegula to reach her third WTA 1000 quarterfinal.

[97] It was also the first time in major history that two Greek players (Sakkari and Tsitsipas) were in the semifinals of a Grand Slam championship.

4 seed Karolína Plíšková to earn a place in only the second major semifinal of her career at the US Open to play qualifier from Great Britain Emma Raducanu.

[105] As a result of reaching the final, she entered the top 10 in the WTA rankings for the first time in her career on 27 September 2021.

Then she defeated Irina-Camelia Begu to reach her fourth career final, where she lost to Anett Kontaveit in three sets.

She defeated Kateřina Siniaková, Petra Kvitová, qualifier Daria Saville and Elena Rybakina to reached her first Indian Wells semifinals.

[116] At the Cincinnati Open, Sakkari lost in the second round to Caroline Garcia in a tough three-set match lasting more than two hours.

[117] She reached her sixth WTA career final at the Emilia-Romagna Open where she was defeated by Mayar Sherif, in straight sets.

[119][120] Sakkari made it to the finals of the Guadalajara Open defeating Marta Kostyuk, Danielle Collins, Veronika Kudermetova and Marie Bouzková en route.

[128] In Linz as the top seed, she advanced to the semifinals by beating Nuria Párrizas Díaz, Varvara Gracheva and Donna Vekić but lost to Petra Martić.

[138] Continuing her campaign on hardcourts, now in the Middle East, Sakkari participated in the Abu Dhabi Open, where as the third seed she lost to Sorana Cîrstea in the first round in straight sets.

[139] She reached her second final at the WTA 1000 Indian Wells Open, and fourth in her career overall at this level, under the tutelage of her new coach David Witt.

[148] Sakkari is the first ambassador of the charity association DESMOS, which since 2012 uplifts vulnerable social groups, through many actions and programs, which are shared in collaboration with more than 800 organizations.