[1] For her doctoral thesis, she applied for the first time in hadron colliders a novel double blind analysis method to search for evidence of supersymmetry.

[3] From 2001 to 2003, Spiropulu continued the CDF experiment as an Enrico Fermi fellow at the University of Chicago, using signatures of missing transverse energy to search for extra dimensions and supersymmetry.

[1] She invented, with her student Chris Rogan and collaborators Maurizio Pierini and Joseph Lykken, a new set of kinematic variables ("razor") targeting the discovery and characterization of new physics at the LHC.

In 2014, she initiated a program to explore and apply quantum computation and artificial intelligence tools towards accelerating discovery in high-energy particle physics and other domain sciences.

[4][5][6][7] Since 2018 Spiropulu has been the PI of the Quantum Communications Channels for Fundamental Physics (QCCFP) project, supported by the QuantISED program of the U.S. Dept.

[8] Accomplishments of this project include the first laboratory demonstration of traversable wormhole teleportation, using a Google Sycamore quantum processor.