In the process, Elizabeth transfers the burden of responsibility to him, fully aware that he in turn will hand over the warrant to Lord Burleigh, and thus confirm Mary's death sentence.
Using Robert David MacDonald's translation, the play was directed by Uzma Hameed and starred Hilary Tones as Elizabeth I and Chloe Angharad as Mary Stuart.
Using Peter Oswald's new translation, it was directed by Phyllida Lloyd and starred Janet McTeer as Mary, Queen of Scots and Harriet Walter as Elizabeth of England.
The production transferred to the Apollo Theatre in London's West End, where it also played a sold-out engagement from late 2005 into January 2006.
The L.A. Theatre Works of Los Angeles mounted a production of the Peter Oswald translation in 2007 directed by Rosalind Ayres which was recorded on CD (ISBN 978-1580813754) and featured Alex Kingston as Mary, Jill Gascoine as Elizabeth, Martin Jarvis as Burleigh, Simon Templeman as Leicester, Ken Danziger as Paulet, W. Morgan Sheppard as Talbot, Christopher Neame as Davison, Shellagh Cullen as Hanna Kennedy and Seamus Dever as Mortimer.
The cast included Meg Fraser as Mary, Alexandra Mathie as Elizabeth, Matthew Pidgeon as Mortimer, Robin Laing as Leicester, Richard Greenwood as Burleigh and Paul Young as Shrewsbury.
[4] The Stratford Shakespeare Festival ran a production in 2013 at the Tom Patterson Theatre with the Peter Oswald translation and directed by Antoni Cimolino.
[6] An adaptation by Robert Icke opened at London's Almeida Theatre in 2016, starring Juliet Stevenson and Lia Williams.
At the beginning of each performance the two leading actors were randomly assigned the roles of Elizabeth I and Mary Stuart by the spinning of a coin.