[2] At 18, she moved to France to pursue her acting studies and was a student at the Conservatoire national supérieur d'art dramatique (CNSAD), graduating in 1988.

[4] Medeiros' resemblance to Anaïs Nin landed her the primary role in Henry & June (1990), in which she played the author.

She has starred in the Canadian movie The Saddest Music in the World (2004) directed by Guy Maddin and co-starring Isabella Rossellini and Mark McKinney.

In 2007, Medeiros released the album A Little More Blue[4][6] on which she performs songs by Brazilian musicians, including Chico Buarque, Caetano Veloso, Ivan Lins, and Dolores Duran.

[6] For her fourth album, she teamed up with Phoebe Killdeer & The Shift to produce The Piano's Playing The Devils Tune, released in 2016.