Aslamazyan was the student of Stepan Aghajanian and Petrov-Vodkin and is a representative of the Armenian school of decorative-planar still life paintings and portraits, as well as an accomplished ceramicist.

She also painted overtly Socialist Realist work, which was required of Official artists of the day, most notably The Return of the Hero (1943) for which she was awarded the Medal "For the Defence of the Caucasus.

She received funding through the Artists' Union to travel to numerous countries around the world, including Algeria, Argentina, Belgium, China, German Democratic Republic (today Germany), France, India, Italy, Japan, Madagascar, Spain, Sweden, the Netherlands, United Arab Republic (today Egypt and Syria), and Yugoslavia.

Throughout their career, the sisters represented Armenian culture in numerous cities around the world and never stopped praising Armenia as their first and foremost inspiration in art.

After a reception organized for Nehru prize laureates, Gandhi approached Mariam and started to examine her traditional Armenian silver belt with curiosity.