Born in Berlin, Helms studied musicology (historical musicology and ethnomusicology) and medieval and modern history at the Free University of Berlin from 1955, where she received her doctorate in 1964 with a dissertation on the masses of Johannes Ockeghem.
From autumn 1967 to 1978, she worked as a research assistant at the Johann Sebastian Bach Institute in Göttingen and in 1979 at the Beethoven Archive in Bonn.
From 1980, she was a member of the Joseph Haydn Institute in Cologne.
She worked there as a research assistant and archivist, most recently (from July 1997 to the end of 1998) as scientific director.
[2] In retirement (since 1999), she continued to work as an editor on volumes of the Complete Haydn Edition.