He also was the boss of the mandamento of Mazara, including the Mafia families of Marsala, Salemi and Vita.
[citation needed] In the 1980s, Agate supported the Corleonesi faction during the Second Mafia War and became the most important ally of Totò Riina in the province of Trapani.
In 1985 he was sentenced to life for several murders, including those of judge Giacomo Ciaccio Montalto and the mayor of Castelvetrano, Vito Lipari.
He was sentenced for life for the murders of the Antimafia judges Giovanni Falcone and Paolo Borsellino.
[2] Despite being jailed, in 2004 he was accused of running an international cocaine trafficking ring with several 'Ndrangheta clans (the Marando, Trimboli and Barbaro clans from Platì in particular), supported by his son Epifanio Agate and Salvatore Miceli, a fugitive in Colombia.