Largely forgotten or eclipsed by other writers of the period (such as Madame de La Fayette) in the works of literary historians of the 19th and 20th centuries, Madame de Villedieu is currently enjoying a literary revival.
An interest in love, psychological analysis, moral dilemmas and social constraints permeated these relatively short novels.
A number of these short novels recounted the "secret history" of a famous event, linking the action generally to an amorous intrigue; these were called "histoires galantes".
Her masterpiece is perhaps the pseudo-memoir novel Mémoires de la vie d'Henriette-Sylvie de Molière, a remarkably realistic story (in the vein of a picaresque novel) recounting the economic and emotional misfortunes of a young woman in contemporary French society.
Along with her novels, she wrote three plays: the tragicomedy Manlius performed with critical success by the actors of the Hôtel de Bourgogne in 1662 (the play engendered a debate between Jean Donneau de Visé and François Hédelin, abbé d'Aubignac concerning its historical accuracy); the tragedy Nitétis performed April 27, 1663; and the tragicomedy Le Favori, performed April 24, 1665 at Théâtre du Palais-Royal in Paris and June 13, 1665 at Versailles.