[1] She moved to the Paris-Sud University for graduate studies focused on lasers, before returning to École polytechnique for doctoral research, where she worked on non-linear optics.

Specifically, she studies nonlinear optics of chiral molecules and second-harmonic generation imaging of collagen fibres.

[3][4] Using Hyper–Rayleigh scattering, Schanne-Klein showed that the hyperpolarizability of collagen fibres, which forms the basis of the contrast observed in non-linear optical measurements, occurred due to the coherent amplification of peptide bonds along the lengths of the molecules.

[6] These parchments often contain collagen,[7] and Schanne-Klein showed that non-linear optical microscopy could be used to evaluate degradation within the material.

[6] Schanne-Klein is a professor at the French National Centre for Scientific Research and the École polytechnique.