Marie Anne Simonis (17 January 1758 – 21 November 1831), known as "La Grande Madame", was a Belgian textile industrialist.

Together with her brother, Iwan Simonis, she introduced the mechanization of the textile industry in the territory by adopting the inventions of the British textile industry, such as the Spinning Jenny.

[1] Marie Anne Simonis was born in Verviers on 17 January 1758.

Returning to Verviers when matters had quietened down, she became closely associate with William Cockerill, who produced machines for her husband's factory.

Out of concern for the condition of her workers, she founded schools and hospitals for the poor.