She was born in Waterford, Ireland, a granddaughter of Lucien Bonaparte (making her Emperor Napoleon I's great-niece) by his second wife, through the marriage of his daughter Letizia to Sir Thomas Wyse, an Irishman, British plenipotentiary at Athens, and Member of Parliament.

In December 1848, aged seventeen, Marie (secretly called Marie-Studholmine) married Frédéric Joseph de Solms (1815–63), a rich gentleman from Strasbourg who soon left her to go to America.

Marie, known as the "Princess de Solms", remained with her mother, who kept a brilliant salon in Paris frequented by Victor Hugo, Eugène Sue, the younger Alexandre Dumas, and other writers.

In August 1853 Marie settled at Aix-les-Bains in Savoy, then part of the Kingdom of Sardinia, where her lover (Pommereu) built her a chalet that soon became the center of a new literary salon.

This was done as part of an agreement concluded by the king's prime minister, Count Cavour, to guarantee French support for Sardinia in the oncoming war to free northern Italy from Austrian occupation.

After his death in June 1873, Madame Rattazzi returned to Paris, and a few months later married her Spanish friend, under-secretary Don Luis de Rute y Ginez (1844–89), whom she also outlived.