From 1707, her father's cousin, Frederick Ulrich, Count of East Frisia, heir of Kriechingen and the lordships of Saarwellingen, Crieching, Puttlingen and Rollingen, courted her.

The only child of the marriage was a daughter, Christine Louise (* February 1, 1710; † May 12, 1732), who married Count Johann Ludwig of Wied-Runkel (* May 30, 1705; † May 18, 1762) in 1726.

After the death of her husband, Marie Charlotte managed the inheritance of her underage daughter until 1726.

[3][4] After the House of Cirksena died out in the male line in 1744, Marie Charlotte and her sister Friederike Wilhelmine (1695–1750), tried in vain to take over the county.

Instead, Frederick II of Prussia prevailed and incorporated East Frisia into his domain.