Ludwig Philipp acted as the administrator of the Electoral Palatinate, but was expelled again in 1635 by imperial troops.
Marie Eleonore and her husband lived in exile in Metz and Sedan for a few years.
However, Marie Eleonore, described as energetic, resisted these efforts with the support of her grandnephew, Elector Friedrich Wilhelm von Brandenburg, and asserted her regency.
Holy Roman Emperor Ferdinand III confirmed her on 6 July 1655 as regent of the principality, pending the adulthood of her son.
Louis Philip and Marie Eleonore had seven children, only two of whom survived to adulthood.