Marie Heilbron (or Heilbronn, 5 May 1851 - 31 March 1886) was a Belgian operatic coloratura soprano, particularly associated with the French repertory, creator of Jules Massenet's quintessential French heroine Manon.

Born in Antwerp, she studied first in Brussels and later in Paris with famous tenor Gilbert Duprez.

She made her Parisian debut at the Théâtre-Italien in 1866, as Marie in La fille du régiment.

In 1867, she appeared for the first time at the Opéra-Comique, as Catherine in L'étoile du nord.

She took part in the creation of Jacques Offenbach's Les braconniers, and Victor Massé's Une nuit de Cléopâtre.