The photographs she created of rural life in 1920s Lebanon are considered to constitute a valuable and unique record of their time and place.
She sometimes posed her subjects and dressed them in particular clothing, such as in her striking "Two Women Disguised as Men", which is a portrait of herself and her sister Alice smoking and wearing Western business suits, under a large painted portrait of their grandfather, Shaykh Sa'id al-Khazen.
[3] Of this photograph, the New York Times art critic Adam Shatz said "Such pictures don't come along often, but once seen, they are impossible to forget, lodging themselves in the mind with the visceral force of revelation.
"[4] Other photographs depict al-Khazen's interests in fishing, hunting, and driving automobiles.
[3] Marie al-Khazen gave a box of over 100 negatives to journalist Mohsen Yammine sometime in the 1970s.