She joined the Abbey of the Ordre des Religieuses de Notre-Dame in Toulouse in 1717.
She herself successfully asked permission from the king to found a convent school in the colony, through the mediation of a Jesuit.
Marie de Cambolas wished to include coloured girls in the school but this was initially refused.
The danger was avoided, and the people of the city attributed this unexpected development to the prayers of Marie de Cambolas, and hailed her as the heroine of Cap-Français.
Marie de Cambolas was described as an ascetic, who devoted herself heavily to penitent actions.