[1] After the death of her husband, she became regent of the County of Vendôme as the guardian of her son, Charles de Bourbon.

[3] She belonged to the French cadet branch of a dynasty which had reigned as Dukes of Luxembourg, and whose senior line produced several Holy Roman Emperors before eventually becoming extinct in 1437.

Marie was first married as a child to her maternal uncle, Jacques of Savoy, Count of Romont.

This happened shortly before Marie's prospects as heiress were greatly diminished following her grandfather, the French constable Louis de Luxembourg, Count of Saint-Pol's, execution for treason in 1475; which entailed the sequestration of his property.

Marie's status and part of her French inheritance were restored upon her remarriage to Francis de Bourbon, Count of Vendôme, a prince du sang, in 1487.