On 29 November 1328, Marie was betrothed to Guy of Lusignan, titular Prince of Galilee at the Château de Bourbon.
The correspondence of Pope Clement VI includes a letter of condolences for the demise of Guy, dated to 24 September 1343.
On 3 November 1347, Louis I of Hungary, older brother of Andrew, invaded the Italian Peninsula in a retaliation campaign.
In 1348, the Black Death reached the Italian Peninsula, forcing Louis I and the majority of his army to retreat back to the Kingdom of Hungary in hope of escaping the spreading epidemic.
Marie benefited by the brief campaign as Robert transferred to her lands in Corfu, Kefalonia and the fiefdom of Kalamata (part of the Principality of Achaea).
His marriage with Marie had been childless and his legal heir was his younger brother Philip II of Taranto.
Hugh was still unable to claim the throne of Cyprus but his uncle Peter I named him Prince of Galilee in 1365.
However Hugh saw another opportunity to claim the throne of Cyprus and left the Peloponnese to travel to Nicosia, effectively abandoning his campaign.
Unable to secure victory, Marie sold her rights to Philip II, Prince of Taranto for 6,000 gold pieces.
The last will and testament of Marie names her nephew Louis II, Duke of Bourbon as her sole heir.