She was the daughter of John I, Duke of Brabant and Margaret of Flanders.
The marriage was arranged when Savoy joined Brabant in an alliance with France against England.
The wedding took place at the Château de Chambéry in 1298.
Marie appears to have had some influence at court, playing a role as diplomat and political adviser.
When her sister and brother-in-law travelled to Italy in 1310, they visited Maria at the court of Savoy in Geneva on their way to Rome.