Anna of Savoy, born Giovanna (1306–1365), was a Byzantine Empress consort, as the second spouse of Andronikos III Palaiologos.

In his absence, Patriarch John XIV of Constantinople and courtier Alexios Apokaukos convinced Anna that the senior advisor was her enemy.

Anna declared Kantakouzenos an enemy of the state and offered the title of eparch of Constantinople to Apokaukos.

He still controlled part of the Byzantine army, and his claim to the throne began a civil war that lasted until 1347.

In August, 1343, Anna pawned the Byzantine crown jewels to the Republic of Venice for 30,000 ducats as part of an attempt to secure more finances for the war.

Her last official act was the donation of a convent in the memory of Agioi Anargyroi (Greek: «Άγιοι Ανάργυροι» "The Angels Without Money").

Agioi Anargyroi is the joined description of Saints Cosmas and Damian, who supposedly offered free medical services.